药品名称：Valcyte（缬更昔洛韦）
药品别名：英 文 名：Valganciclovir Tablets
药品价格：$ 请咨询微信客服
研发公司：罗氏
适 用 症：用于获得性免疫缺陷综合征(AIDS)患者巨细胞病du(CMV)性视网膜炎
型号规格：450mg
缬更昔洛韦Valcyte适应症
用于获得性免疫缺陷综合征(AIDS)患者巨细胞病du(CMV)性视网膜炎。
禁忌症
1.禁用于对valcyte过m者。
2.中性粒细胞＜0.5×109/L、血小板＜25×109/L、血红蛋白浓度＜80g/L者禁用。
3.血液透析患者禁用本品。
4.本品用于儿童的安q性和尚未确定，故儿童不建议使用。
注意事项
1.肾功能不全患者应慎用本品，并适当调整剂量。yun妇慎用。原先存在骨髓抑制者、接受骨髓抑制药w或放疗，及有血细胞减少症史或血细胞减少反应者慎用。
2.由于本品和更昔洛韦的生物利用度不同，因此不能一对一地替换用药。
3.由于Valcyte的诱变作用可严重影响精子生成和生育能力，因此用药者在治liao期间及治liao后zhi少90天应采取避yun措施。
4.过量服用可能导致肾du性增加，血液透析和增加电解质可能有助于降d血浆药w浓度。
5.15～30℃保存
缬更昔洛韦Valcyte不良反应
1.胃肠道反应
腹泻、恶心、呕吐和。
2.血液系统反应
中性粒细胞减少和贫血、血小板减少、骨髓抑制。
3.s经系统反应
发热、、、外周s经障碍、感觉异常、癫痫、精s病、幻觉。
4.眼部反应
视网膜脱离。
5.其他不良反应
肾功能减退、其他局部或全身反应。在动物试验中更昔洛韦有致癌性、致畸性，并导致无精子生成。
药w相应作用
1.齐多夫定、麦角酚酸酯或硫唑嘌呤与本品合用，使中性粒细胞减少和贫血等不良反应增加。
2.肾du性药w损害肾功能，使更昔洛韦的体内消chu减慢，药w蓄积，du性增加。
3.丙磺舒和其他肾排泄药w能降d更昔洛韦的清chu率，也导致其du性增加。
4.与其他细胞du药w合用会增大骨髓抑制、消化道和皮肤不良反应的危险，因此不能合用。
5.缬更昔洛韦的代谢产物更昔洛韦可显著增加去羟肌苷的生物利用度，应密切观察后者引起的du性反应。
6.与亚胺培南/西司他丁合用会增加癫痫的可能。
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